Postdoctoral fellow
Solliciteer

Postdoctoral fellow

Jouw functie

The Faller lab is seeking a talented and enthusiastic PostDoc to investigate how heterogeneity in ribosomes drives phenotypes in normal epithelial tissues and in cancer.

Project
The project involves the study of ribosome heterogeneity using in vivo intestinal models and 3-d organoid culture. The roles of differing ribosomal populations is unknown in the intestine, and this project aims to study this using use in vivo models and state-of-the-art genomics technology. Our ultimate goal is to develop technologies to study ribosomal heterogeneity, and to use these techniques to understand how ribosomal populations drive tumour formation and growth.

Jouw profiel

We are seeking a Postdoc who has been awarded (or in the final stages of obtaining) a PhD in a field relevant to cancer biology or RNA translation. You will have published (or be about to publish) in a peer-reviewed journal, be able to communicate scientific ideas effectively and have a demonstrable capability for independent thinking. Experience with in vivo models and approaches to study ribosomes (such as polysome profiling) are also desirable but not required.

The Netherlands Cancer Institute (NKI) is an independent research institute located in the lively city of Amsterdam. The Institute covers all major areas of molecular and cellular cancer biology, with special emphasis on mouse tumour models, functional screens, cancer cell biology and translational research. The Netherlands Cancer Institute and the Antoni van Leeuwenhoek Hospital form an integrated cancer centre, combining a research laboratory and a hospital under one roof in a single, independent organization. All hospital departments have an extensive research program, often in close collaboration with the research laboratory. This research is focused on improving cancer treatment through imaging and molecular diagnostics, new medicine, improved operating techniques, more effective radiotherapy, and combinations of these, epidemiology and psychosocial research.

State-of-the-art facilities
The research groups at the NKI-AVL are supported by state-of-the-art equipment and facilities, most with dedicated support staff. The Institute has a large mouse facility with special units for transgenics, intervention studies, pathology and functional imaging, a genomics facility, a functional screening facility for RNAi and small-molecule libraries, excellent facilities for microscopy, flowcytometry, protein expression and purification, and many more.

Inspiring international atmosphere
Approximately 550 people work in the research laboratory and many of the clinicians are involved in research. Work discussions, lectures and seminars are in English and a large number of non-Dutch post-docs, students and staff members contribute to the stimulating and international atmosphere of the Institute.

Jouw ontwikkelingsmogelijkheden en arbeidsvoorwaarden

We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction, salary scale 55-60 according to the Collective Labour Agreement General Hospitals based on proven qualifications) and housing facilities in the vicinity of the Institute. The appointment is for a period of at least 2 years, with the potential for extension.

Salary
You will be part of the Netherlands Cancer Institute (NKI), a world-class cancer research institute with many international employees and the excellent Antoni van Leeuwenhoek cancer hospital. We provide an open, interactive and stimulating environment with access to top-notch facilities and with many opportunities to interact with colleagues at social events, attend high-quality seminars and perform translational research.

The initial appointment will be for 1 year, with the intention to extend to 4 years in total. The gross salary per month will range from € 3.375,- to € 4.111,- according to FWG-function group 55 and depends on previous experience. The terms of employment will be in accordance with the CAO Ziekenhuizen (Collective Labour Agreement for Hospitals).

Information
For further information visit our home page (https://www.nki.nl/divisions/oncogenomics/faller-william-group/)

The closing date for applications is 25/09/20.